FOXO4-DRI is a cutting-edge therapeutic peptide designed to target cellular senescence. Part of the Forkhead box O (FOXO) family, this peptide offers promising benefits such as reducing oxidative stress, enhancing tissue regeneration, and potentially mitigating aging-related diseases. At Direct Peptides, researchers and practitioners alike are taking a closer look at FOXO4-DRI’s potential to revolutionize how we approach age-related decline because let’s face it, no one wants their cells waving the white flag too early.
FOXO4-DRI is a synthetic peptide engineered to disrupt the interaction between FOXO4 and p53 proteins in senescent cells. By breaking this bond, it restores the ability of damaged cells to undergo apoptosis—the natural cell death process that senescent cells often resist. This selective clearance helps remove dysfunctional cells without harming healthy ones, making FOXO4-DRI a promising candidate in anti-aging and regenerative medicine.
Senescent cells accumulate over time due to stressors like oxidative damage and DNA errors, contributing to tissue dysfunction and age-related disorders. FOXO4-DRI blocks FOXO4’s protective grip on p53, allowing p53 to initiate apoptosis and clear these problematic cells.
Currently, FOXO4-DRI is under active investigation in laboratory and animal studies to evaluate its biological activity, solubility in solvents such as DMSO, and overall therapeutic potential. Proper storage and adherence to Good Manufacturing Practices (GMP) are essential to preserve its purity and effectiveness.
The peptide works by mimicking the FOXO4 region that binds to p53, competitively inhibiting this interaction. Normally, FOXO4 holds p53 captive in senescent cells, preventing apoptosis. FOXO4-DRI frees p53, enabling it to trigger programmed cell death selectively in senescent cells, sparing healthy tissue. If you're seeking access to this cutting-edge compound, you can Buy FOXO4-DRI Peptide Saudi Arabia through specialized suppliers catering to longevity research.
This targeted mechanism not only minimizes side effects but also promotes tissue rejuvenation and slows age-related decline, making FOXO4-DRI an innovative agent in cellular longevity therapies.
Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-Gly-Gly-Lys-Arg-Pro-DL-Pro-DL-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-OH
Molecular Formula: C228H388N86O64
Molecular Weight: 5358 g/mol
PubChem CID: 168431240
Targeted Senescence Clearance: Promotes apoptosis in senescent cells by disrupting FOXO4-p53, reducing the harmful buildup of damaged cells linked to aging.
Anti-Aging Effects: Clears senescent cells to improve tissue function and enhance overall physiological resilience.
Longevity Potential: By addressing cellular aging at its core, FOXO4-DRI could contribute to lifespan extension and quality of life improvements.
Enhanced Tissue Regeneration: Removing senescent cells allows better cellular renewal and repair throughout the body.
Treatment of Age-Related Diseases: Shows promise in conditions like osteoarthritis, atherosclerosis, and other diseases driven by senescent cell accumulation.
Cardiovascular Health: May improve heart function by reducing senescent cells in cardiac tissue, potentially delaying age-related cardiac decline.
Neurodegenerative Disorders: Potential to slow diseases such as Alzheimer’s and Parkinson’s by clearing senescent cells in the nervous system.
Hypogonadism and Hormonal Balance: Could aid hormonal health by targeting senescent cells in reproductive tissues.
Hair Loss Mitigation: Supports healthier hair follicles by reducing cellular senescence related to aging or stress-induced thinning.
Chronic Inflammation Reduction: Clearing senescent cells may lower inflammation caused by the Senescence-Associated Secretory Phenotype (SASP).
Precision Therapy: Selectively targets senescent cells, sparing healthy cells and reducing side effects common to less specific treatments.
Available as 10mg pre-mixed cartridge kits that include the peptide, bacteriostatic water, a pen, a carry case, and needle tips. Single cartridges are also offered with needle tips but without the full kit. Save 10% when purchasing three cartridges.
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“DRI” (Retro-Inverso) peptides are synthetic analogs designed to enhance stability and bioavailability without losing biological function. By reversing the amino acid sequence and substituting L-amino acids with D-amino acids, these peptides resist enzymatic breakdown and penetrate cell membranes more effectively, boosting therapeutic efficacy and durability.
FOXO4-DRI nasal spray is available in 15 ml and 30 ml bottles. This delivery method bypasses oral and injectable routes, providing faster absorption and a less invasive option. Though still in early research stages, it may revolutionize senolytic therapies targeting aging and related diseases.